One-pot synthesis of surface roughness controlled hollow silica spheres with enhanced drug loading and release profile under ambient conditions in aqueous solutions.
نویسندگان
چکیده
A green one-pot approach is used to synthesize surface morphology controlled hollow silica spheres in aqueous solution under ambient conditions. Using cationic polystyrene particles as a template and aminopropyltriethoxysilane (APTES) as a structural directing agent, the surface roughness and wall thickness could be easily controlled by varying the concentration of tetraethoxysilane (TEOS). Smooth surface of hollow silica spheres with different wall thickness was obtained using anionic polystyrene particles. The resulted hollow silica spheres with rough surface had better performance in carrying and releasing a model drug.
منابع مشابه
Synthesis and Study of Lidocaine Hydrochloride from Polymeric Film as a Wound Dressing
Introduction: Among various carrier materials capable of drug controlled-release, silica xerogels have been found to be noteworthy for loading and sustaining drug release. These silica xerogels were synthesized through sol-gel technology using Tetraethylortosilicate (TEOS) as a silica precursor. Methods: This study was an experimental basic research, which aimed to characterize the effect of a...
متن کاملHollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery
Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make th...
متن کاملSynthesis and Characterization of Novel Modified and Functionalized Silica Nano-particles for Protein Delivery Applications
In this study, the synthesis, characterization and controlled release behavior of new Hollow Silica Nano particles (HSNPs) and Magnetic Silica Nano Particles (MSNPs) were studied. Magnetic Silica Nano particles (MSNPs), as drug delivery vehicles, were synthesized through the coating of Fe3O4 nano-crystals with silica layers. The HSNPs were obtained by removal of Fe3O4 templates with hydrochlori...
متن کاملAdsorption of Fluconazole Drug on Silica Aerogel by Immersion Method and Investigation of the Rate and Mechanism of Drug Release
In this study, adsorption of fluconazole on silica aerogel was performed successfully by the immersion method in the 1% solution of fluconazole-ethanol at the ambient condition and without using the supercritical method. The hydrophobic and hydrophilic silica aerogels were synthesized by the two-stage sol-gel method and dried at the ambient temperature. This method had most of drug loading at 2...
متن کاملMesoporous Silica Nanoparticles as a Nanocarrier for Delivery of Vitamin C
Background: In the last decades, mesoporous silica nanoparticles (MSN) are improved for drug delivery, imaging, and biomedical applications due to their special properties such as large surface area, high drug loading capacity, tunable pore size, and modification of surface area by functional groups. Objectives: The aim of this study was to evaluate MSNs as carriers for oral colon-specific and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of materials chemistry. B
دوره 1 40 شماره
صفحات -
تاریخ انتشار 2013